You can take them together or alternate between the two every two hours (for example 10am co codamol, 12am ibuprofen, 14pm co codamol, 16pm ibuprofen). I only took 3 Ibuprofens each day for the first two days as I don’t get on with Co Codamol and I’m not a big fan of painkillers. That’s probably why I was in a bit of pain for a longer time but I feel so much better now. Happy healing xxx